Effects of glucocorticoids on the hypothalamic-pituitary-adrenal (HPA) axis. This scheme shows the sites of synthesis and action of the main HPA hormones and the targets of glucocorticoid action (see text for details). Based on analysis of dimerisation defective mice many of the effects of glucocorticoids are labelled as either dependent on (D) or independent of (I) GR DNA binding. Question marks indicate uncertainty as to the mechanism of action. Abbreviations are to be found in the text. Adapted from Reichardt and Schutz. ...
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